Besieged Prime Minister Malcolm Turnbull's leadership looks doomed, after three of his senior ministers announced they had tendered their resignations and called for a second leadership vote.
The ministers, who supported Mr Turnbull in a leadership ballot on Tuesday against former home affairs minister Peter Dutton, said they had changed their position and now backed Dutton.
Mr Turnbull only won the Tuesday contest by seven votes. Mr Dutton on Thursday publicly called for another leadership vote.
Finance Minister Mathias Cormann, Turnbull's key cabinet supporter who tendered his resignation, said he now believed that Mr Dutton was the best person to lead the conservative government to the next election, due by May 2019.
"I can't ignore reality," Mr Cormann said as he announced he was withdrawing support for Turnbull, adding five other ministers who voted for Turnbull on Tuesday had told him they were changing sides.
"I can't ignore the fact that a majority of colleagues in the Liberal Party... are of the view that there should be a change," he said.
Mr Turnbull is reportedly unlikely to contest a second leadership ballot, making way for Treasurer Scott Morrison as a surprise challenger for the top job.
Mr Morrison has been a Turnbull supporter, but has reportedly long held ambitions on the prime ministership.
Whoever emerges as Australia's next prime minister, they will become the country's seventh prime minister in a decade.
Turnbull came to power in a party-room coup in September 2015 over former premier Tony Abbott, who also survived an internal leadership contest before his eventual defeat.
A social liberal and multi-millionaire former merchant banker, Mr Turnbull rode an early wave of popular support but he has struggled to appeal to conservative voters and only narrowly won an election in 2016.
The ruling Liberal-National coalition government has consistently trailed the opposition Labor party in opinion polls, but Mr Turnbull has remained the voters' preferred prime minister over Labor leader Bill Shorten.
Australia's continued political instability has fuelled anger and frustration among voters and hindered investment by the business sector.
"For everybody in the country what is happening in Canberra is disappointing and frustrating. Business likes certainty and confidence in what happens in the future. Anytime we see uncertainty like is happening in Canberra it is not helpful," Qantas chief executive Alan Joyce said.